Metal-Free sp3 C–H Bond Dual-(Het)arylation: I2-Promoted Domino Process to Construct 2,2-Bisindolyl-1-arylethanones
Organic Letters2012Vol. 14(13), pp. 3392–3395
Citations Over TimeTop 10% of 2012 papers
Abstract
A molecular I(2)-promoted sp(3) C-H bond dual-(het)arylation protocol was developed for the synthesis of 2,2-bisindolyl-1-arylethanones. Through a logical design, three mechanism-different reactions (iodination, Kornblum oxidation, and Friedel-Crafts reaction) were assembled in a single reactor. A variety of 2,2-bisindolyl-1-aryl ethanones were synthesized from simple and readily available aryl methyl ketones and indoles. In the reaction, metal, base, and ligand were all avoidable.
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