A “Catch–React–Release” Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base
Organic Letters2012Vol. 14(15), pp. 3920–3923
Citations Over TimeTop 10% of 2012 papers
Abstract
The development of a monolith-supported synthetic procedure is reported, taking advantage of flow processing and the superior flow characteristics of monolithic reagents over gel-phase beads, to allow facile access to an important family of 2-aminopyrimidine derivatives. The process has been successfully applied to a key precursor on route to Imatinib (Ar = 3-pyridyl, R(1) = 2-methyl-5-nitrobenzyl, R(2) = H).
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