Enantioselective Construction of 3-Hydroxy Oxindoles via Decarboxylative Addition of β-Ketoacids to Isatins
Organic Letters2012Vol. 14(15), pp. 4018–4021
Citations Over TimeTop 10% of 2012 papers
Abstract
The first highly enantioselective decarboxylative addition of β-ketoacids to isatins mediated by a bifunctional tertiary amine-thiourea catalyst has been developed, allowing facile synthesis of biologically important 3-hydroxy oxindoles in good yields and excellent enantioselectivities. The method reported represents a valuable approach of utilizing β-ketoacids as synthetic equivalents of aryl/alkyl methyl ketone enolates.
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