Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3
Organic Letters2012Vol. 14(17), pp. 4478–4481
Citations Over TimeTop 10% of 2012 papers
Gopal Chandru Senadi, Wan‐Ping Hu, Jia‐Shing Hsiao, Jaya Kishore Vandavasi, Chung‐Yu Chen, Jeh‐Jeng Wang
Abstract
An expedient method for a direct approach to the selective and regiocontrolled synthesis of 2-oxazolines and 2-oxazoles mediated by ZnI(2) and FeCl(3) is described. A Lewis acid promoted cyclization of acetylenic amide with various functionalities was well tolerated to give 2-oxazolines and 2-oxazoles in good to excellent yields under mild reaction conditions.
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