Hydrogen Bonding Directed Intermolecular Cope-Type Hydroamination of Alkenes
Organic Letters2012Vol. 14(19), pp. 5082–5085
Citations Over TimeTop 10% of 2012 papers
Abstract
Intermolecular hydroamination of unactivated alkenes represents a significant synthetic challenge. An efficient Cope-type hydroamination is achieved under mild conditions for reactions of N-alkylhydroxylamines with allylic amines, using hydrogen bonding to achieve increased reactivity and high regioselectivity. This approach provides a number of highly functionalized vicinal diamine motifs as Markovnikov addition products.
Related Papers
- → Anti-Markovnikov Hydroamination of Terminal Alkynes(2002)169 cited
- → Iron‐Catalyzed Anti‐Markovnikov Hydroamination of Vinylpyridines(2017)7 cited
- → ChemInform Abstract: Catalytic Tandem Markovnikov Hydroamination‐Alkynylation and Markovnikov Hydroamination—Hydrovinylation.(2015)
- → Syn-Selective anti-Markovnikov Intramolecular Hydroamination(2006)
- → Intramolecular Anti-Markovnikov Hydroamination of Alkenes(2013)