CuI Controlled C–C and C–N Bond Formation of Heteroaromatics through C(sp3)–H Activation
Organic Letters2012Vol. 14(21), pp. 5546–5549
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Abstract
A new method for C-C and C-N bond formation of heteroaromatics and C(sp(3))-H alkanes was developed with high regioselectivity. The reaction occurred on C8 to give 8-cylcoakylpurines by C-C bond formation only promoted by tBuOOtBu, while it occurred on the amino group to give N6-alkylated purines by C-N bond formation when 2 equiv of CuI were added. A reaction mechanism was also proposed based on our preliminary experimental data.
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