Direct Conversion of Indoles to 3,3-Difluoro-2-oxindolesviaElectrophilic Fluorination
Organic Letters2012Vol. 14(22), pp. 5676–5679
Citations Over TimeTop 12% of 2012 papers
Abstract
3,3-Difluoro-2-oxindoles can be obtained directly from indoles in moderate yields via electrophilic fluorination using N-fluorobenzenesulfonimide as a mild fluorinating reagent. The presence of tert-butyl hydroperoxide during the reaction, together with additional heating after quenching the reaction with triethylamine, is beneficial to the formation of the desired product.
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