Siladenoserinols A–L: New Sulfonated Serinol Derivatives from a Tunicate as Inhibitors of p53–Hdm2 Interaction
Organic Letters2012Vol. 15(2), pp. 322–325
Citations Over TimeTop 19% of 2012 papers
Yuichi Nakamura, Hikaru Kato, Tadateru Nishikawa, Noriyuki Iwasaki, Yoshiaki Suwa, Henki Rotinsulu, Fitje Losung, Wilmar Maarisit, Remy E. P. Mangindaan, Hiroshi Morioka, Hideyoshi Yokosawa, Sachiko Tsukamoto
Abstract
Siladenoserinols A–L were isolated from a tunicate as inhibitors of p53–Hdm2 interaction, a promising target for cancer chemotherapy. Their structures including the absolute configurations were elucidated to be new sulfonated serinol derivatives, each of which contains a 6,8-dioxabicyclo[3.2.1]octane unit and either glycerophosphocholine or glycerophosphoethanolamine moiety. They inhibited p53–Hdm2 interaction with IC50 values of 2.0–55 μM. Among them, siladenoserinol A and B exhibited the strongest inhibition with an IC50 value of 2.0 μM.
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