Fluorous Supported Modular Synthesis of Heparan Sulfate Oligosaccharides
Organic Letters2013Vol. 15(2), pp. 342–345
Citations Over TimeTop 10% of 2013 papers
Abstract
The modular synthesis of heparan sulfate fragments is greatly facilitated by employing an anomeric aminopentyl linker protected by a benzyloxycarbonyl group modified by a perfluorodecyl tag, which made it possible to purify highly polar intermediates by fluorous solid phase extraction. This tagging methodology made it also possible to perform repeated glycosylations to drive reactions to completion.
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