A Highly Convergent and Efficient Synthesis of a Macrocyclic Hepatitis C Virus Protease Inhibitor BI 201302
Organic Letters2013Vol. 15(5), pp. 1016–1019
Citations Over TimeTop 12% of 2013 papers
Xudong Wei, Chutian Shu, Nizar Haddad, Xingzhong Zeng, Nitinchandra D. Patel, Zhulin Tan, Jianxiu Liu, Heewon Lee, Sherry Shen, Scot Campbell, Richard J. Varsolona, Carl A. Busacca, Azad Hossain, Nathan K. Yee, Chris H. Senanayake
Abstract
A highly convergent large scale synthesis of a 15-membered macrocyclic hepatitis C virus (HCV) protease inhibitor BI 201302 was achieved, in which the key features are the practical macrocyclization by Ru-catalyzed ring-closing metathesis (0.1 mol % Grela catalyst, 0.1-0.2 M concentration) and the efficient sulfone-mediated SNAr reaction.
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