Silver-Catalyzed Incorporation of Carbon Dioxide into o-Alkynylaniline Derivatives
Organic Letters2013Vol. 15(4), pp. 848–851
Citations Over TimeTop 10% of 2013 papers
Abstract
Benzoxazine-2-one derivatives are important heterocycle structures because of their various pharmaceutical activities, though their synthetic methods had been limited. In some cases, toxic reagents, such as phosgene or carbon monoxide, are required. It was found that a silver catalyst successfully promoted the incorporation of CO(2) into o-alkynylanilines to afford the corresponding benzoxazine-2-ones bearing Z exo-olefin via 6-exo-dig cyclization at the activated C-C triple bond.
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