Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B from the Culture of Aspergillus sp. 16-5c
Organic Letters2013Vol. 15(4), pp. 721–723
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Xishan Huang, Hongbo Huang, Hanxiang Li, Xuefeng Sun, Huarong Huang, Yongjun Lu, Yongcheng Lin, Yuhua Long, Zhigang She
Abstract
Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC(50) value of 2.2 μM.
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