Synthesis of Functionalized Allenamides from Ynamides by Enolate Claisen Rearrangement
Organic Letters2013Vol. 15(7), pp. 1626–1629
Citations Over TimeTop 10% of 2013 papers
Abstract
The Claisen rearrangement of N-Boc glycinates derived from ynamido-alcohols affords an efficient and stereoselective access to highly functionalized allenamides. These compounds undergo silver-catalyzed cyclization to 3-pyrrolines which are useful precursors for the synthesis of substituted pyrrolidines.
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