Hippolachnin A, a New Antifungal Polyketide from the South China Sea Sponge Hippospongia lachne
Organic Letters2013Vol. 15(14), pp. 3526–3529
Citations Over TimeTop 10% of 2013 papers
Shu‐Juan Piao, Yunlong Song, Wei‐Hua Jiao, Fan Yang, Xiang‐Fang Liu, Wansheng Chen, Bingnan Han, Hou‐Wen Lin
Abstract
Hippolachnin A (1), a polyketide possessing an unprecedented carbon skeleton with a four-membered ring, was isolated from the South China Sea sponge Hippospongia lachne. The structure was elucidated using MS and NMR spectroscopic analyses, and the absolute configuration was determined using a calculated ECD method. Hippolachnin A demonstrated potent antifungal activity against three pathogenic fungi, Cryptococcus neoformans, Trichophyton rubrum, and Microsporum gypseum, with a MIC value of 0.41 μM for each fungus.
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