Aldol Reactions in Multicomponent Reaction Based Domino Pathways: A Multipurpose Enabling Tool in Heterocyclic Chemistry
Organic Letters2013Vol. 15(11), pp. 2738–2741
Citations Over TimeTop 10% of 2013 papers
Abstract
The aldol reaction has been evaluated in combination with the Ugi multicomponent reaction to assemble richly decorated mono- and polycyclic systems via expeditious cascade pathways. A small collection of pyrrolinones was generated thereof, and the scarcely accessible pyridoquinoxalinedione scaffold was also prepared by designing an additional nucleophilic substitution step in this domino sequence requiring minimal operational effort.
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