Interrupted Fischer-Indole Intermediates via Oxyarylation of Alkenyl Boronic Acids
Organic Letters2013Vol. 15(13), pp. 3362–3365
Citations Over TimeTop 15% of 2013 papers
Abstract
The oxyarylation of alkenyl boronic acids with N-arylbenzhydroxamic acids has been achieved under both copper-mediated and copper-catalyzed conditions to provide access to interrupted Fischer-indole intermediates. This transformation is believed to proceed through a copper-promoted C-O bond forming event followed by a [3,3] rearrangement. The scope of the method is described and mechanistic experiments are discussed.
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