Palladium-Catalyzed Oxidative Aminocarbonylation: A New Entry to Amides via C–H Activation
Organic Letters2013Vol. 15(13), pp. 3370–3373
Citations Over TimeTop 10% of 2013 papers
Abstract
A novel palladium-catalyzed oxidative aminocarbonylation reaction via C(sp(3))-H activation was established, which provides a convenient and general method for the construction of arylacetamides via the carbonylation reaction of alkyl aromatics and amines. By using this protocol, the marketed drug ibuprofen could be easily obtained.
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