Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins
Organic Letters2013Vol. 15(17), pp. 4362–4365
Citations Over TimeTop 12% of 2013 papers
Abstract
A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.
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