S-, N-, and Se-Difluoromethylation Using Sodium Chlorodifluoroacetate
Organic Letters2013Vol. 15(19), pp. 5036–5039
Citations Over TimeTop 10% of 2013 papers
Abstract
A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 °C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol.
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