Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides
Organic Letters2013Vol. 16(1), pp. 154–157
Citations Over TimeTop 1% of 2013 papers
Benjamin N. Rocke, Kevin B. Bahnck, Michael Herr, Sophie Y. Lavergne, Vincent Mascitti, Christian Perreault, Jana Polívková, Andrei Shavnya
Abstract
Organozinc reagents react with the SO2 surrogate DABSO, and the resulting zinc sulfinate salts are alkylated in situ to afford sulfones. This transformation has a broad scope and is compatible with a wide range of structural motifs of medicinal chemistry relevance including nitrile, secondary carbamates, and nitrogen-containing heterocycles.
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