Highly Enantioselective Organocatalytic α-Sulfenylation of Azlactones
Organic Letters2014Vol. 16(3), pp. 672–675
Citations Over TimeTop 10% of 2014 papers
Abstract
The first asymmetric α-sulfenylation of azlactones with N-(sulfanyl)succinimides has been developed by using cinchona alkaloid-derived squaramide as a catalyst and 4 Å molecular sieves as an additive. The reaction conditions were suitable to 4-alkyl and benzyl-substituted azlactones as well as N-(benzyl/alkyl/arylthio)succinimides, affording adducts with high enantioselectivities (81-94% ee).
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