Geminal Silicon/Zinc Reagent as an Equivalent of Difluoromethylene Bis-carbanion
Organic Letters2014Vol. 16(5), pp. 1438–1441
Citations Over TimeTop 10% of 2014 papers
Mikhail D. Kosobokov, Vitalij V. Levin, Artem A. Zemtsov, Марина И. Стручкова, Аlexander А. Korlyukov, Dmitry E. Arkhipov, Alexander D. Dilman
Abstract
A new difluorinated reagent, [difluoro(trimethylsilyl)methyl]zinc bromide, bearing C-Zn and C-Si bonds is described. The reagent is conveniently prepared by cobalt-catalyzed halogen/zinc exchange. It can be coupled with two different C-electrophiles in a stepwise manner (with allylic halides for C-Zn bond and aldehydes for C-Si bond) affording products containing a difluoromethylene fragment.
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