A Scalable and Regioselective Synthesis of 2-Difluoromethyl Pyridines from Commodity Chemicals
Organic Letters2014Vol. 16(6), pp. 1724–1727
Citations Over TimeTop 18% of 2014 papers
Jean‐Nicolas Desrosiers, Christopher B. Kelly, Daniel R. Fandrick, Larry J. Nummy, Scot Campbell, Xudong Wei, Max Sarvestani, Heewon Lee, Alexander Sienkiewicz, Sanjit Sanyal, Xingzhong Zeng, Nelu Grinberg, Shengli Ma, Jinhua J. Song, Chris H. Senanayake
Abstract
A scalable de novo synthesis of difluoromethyl pyridines from inexpensive materials is reported. The pyridyl subunit is built around the difluoromethyl group rather than a late stage introduction of this moiety. This user-friendly approach allows access to a diverse range of substitution patterns on all positions on the ring system and on the difluoromethyl group.
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