Iron-Catalyzed Intermolecular Hydroamination of Styrenes
Organic Letters2014Vol. 16(14), pp. 3620–3623
Citations Over TimeTop 10% of 2014 papers
Abstract
An iron-catalyzed formal hydroamination of alkenes has been developed. It features O-benzoyl-N,N-dialkylhydroxylamines as the electrophilic nitrogen source and cyclopentylmagnesium bromide as the reducing agent for intermolecular hydroamination of styrene and derivatives with good yield and excellent Markovnikov regioselectivity. The reaction presumably proceeds through the iron-catalyzed hydrometalation of styrene followed by electrophilic amination with the electrophilic O-benzoylhydroxylamine.
Related Papers
- → Anti-Markovnikov Hydroamination of Terminal Alkynes(2002)169 cited
- → Iron‐Catalyzed Anti‐Markovnikov Hydroamination of Vinylpyridines(2017)7 cited
- → ChemInform Abstract: Catalytic Tandem Markovnikov Hydroamination‐Alkynylation and Markovnikov Hydroamination—Hydrovinylation.(2015)
- → Syn-Selective anti-Markovnikov Intramolecular Hydroamination(2006)
- → Intramolecular Anti-Markovnikov Hydroamination of Alkenes(2013)