Copper-Catalyzed Aerobic Oxidative Amination of sp3C–H Bonds: Efficient Synthesis of 2-Hetarylquinazolin-4(3H)-ones
Organic Letters2014Vol. 16(14), pp. 3672–3675
Citations Over TimeTop 10% of 2014 papers
Abstract
An efficient synthesis of 2-hetarylquinazolin-4(3H)-ones via copper-catalyzed direct aerobic oxidative amination of sp3C–H bonds has been developed. This tandem oxidation–amination–cyclization transformation represents a straightforward protocol to prepare 2-hetaryl-substituted quinazolinones from easily available 2-aminobenzamides and (2-azaaryl)methanes.
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