Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks
Organic Letters2014Vol. 16(16), pp. 4094–4097
Citations Over TimeTop 10% of 2014 papers
Abstract
A collection of novel, pharmaceutically relevant cubane-containing molecules has been prepared from the commercially available cubane-1,4-dimethylester. A range of synthetic methods have been applied to prepare these cubane building blocks with one or two functional handles to allow easy incorporation into existing medicinal chemistry programs.
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