Peganumine A, a β-Carboline Dimer with a New Octacyclic Scaffold from Peganum harmala
Organic Letters2014Vol. 16(15), pp. 4028–4031
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Kai‐Bo Wang, Ying‐Tong Di, Yu Bao, Chun‐Mao Yuan, Gang Chen, Dahong Li, Jiao Bai, Hongping He, Xiao‐Jiang Hao, Yue‐Hu Pei, Yongkui Jing, Zhan‐Lin Li, Huiming Hua
Abstract
Peganumine A (1), a new dimeric β-carboline alkaloid characterized by a unique 3,9-diazatetracyclo[6.5.2.0(1,9).0(3,8)]pentadec-2-one scaffold, was isolated from the seeds of Peganum harmala. The structure including the absolute configuration was determined by spectroscopic data, X-ray crystallography, ECD calculation, and CD exciton chirality approaches. Compound 1 showed moderate cytotoxic activity against MCF-7, PC-3, and HepG2 cells and selective effects on HL-60 cells with an IC50 value of 5.8 μM.
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