Alkene Hydrofunctionalization Using Hydroxamic Acids: A Radical-Mediated Approach to Alkene Hydration
Organic Letters2014Vol. 16(16), pp. 4304–4307
Citations Over TimeTop 22% of 2014 papers
Abstract
A radical-mediated approach to alkene hydration is described. The present strategy capitalizes on the unique radical reactivity of hydroxamic acids, which are capable of functioning as both synthetically useful oxygen-centered radical species and suitable hydrogen atom-based donors. This reaction manifold has been applied to both alkene hydrations and tandem alkene-alkene carbocyclization processes.
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