Azide Phosphoramidite in Direct Synthesis of Azide-Modified Oligonucleotides
Organic Letters2014Vol. 16(17), pp. 4590–4593
Citations Over TimeTop 17% of 2014 papers
Maksim A. Fomich, Maksim V. Kvach, Maksim Navakouski, Christoph Weise, Alexander V. Baranovsky, Vladimir A. Korshun, Vadim V. Shmanai
Abstract
Azide and phosphoramidite functions were found to be compatible within one molecule and stable for months in solution kept frozen at -20 °C. An azide-carrying phosphoramidite was used for direct introduction of multiple azide modifications into synthetic oligonucleotides. A series of azide-containing oligonucleotides were modified further using click reactions with alkynes.
Related Papers
- → 2‘-Modified Nucleosides for Site-Specific Labeling of Oligonucleotides(2001)13 cited
- → Insertion of Chemical Handles into the Backbone of DNA during Solid‐Phase Synthesis by Oxidative Coupling of Amines to Phosphites(2023)4 cited
- → Nucleotides, Part LXIX, Synthesis of Phosphoramidite Building Blocks of IsoxanthopterinN8-(2′-Deoxy-β-D-ribonucleosides): New Fluorescence Markers for Oligonucleotide Synthesis(2001)15 cited
- → New phosphoramidite derivatives for the preparation of oligonucleotides containing a hydrazide group in any specified position of the oligonucleotide chain(2005)3 cited
- Synthesis of an Oligonucleotide Probe Containing Trityl-protected Sulphydryl Group and Tagging with a Fluorescent Dye(2001)