Cycloadditions of Noncomplementary Substituted 1,2,3-Triazines
Organic Letters2014Vol. 16(19), pp. 5084–5087
Citations Over TimeTop 10% of 2014 papers
Abstract
The scope of the [4 + 2] cycloaddition reactions of substituted 1,2,3-triazines, bearing noncomplementary substitution with electron-withdrawing groups at C4 and/or C6, is described. The studies define key electronic and steric effects of substituents impacting the reactivity, mode (C4/N1 vs C5/N2), and regioselectivity of the cycloaddition reactions of 1,2,3-triazines with amidines, enamines, and ynamines, providing access to highly functionalized heterocycles.
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