Gold-Catalyzed Hydroamination/Cycloisomerization Reaction of 1,6-Enynes
Organic Letters2007Vol. 9(20), pp. 4049–4052
Citations Over TimeTop 10% of 2007 papers
Abstract
An efficient Au(I) catalytic system is described for the hydroamination/cycloisomerization reaction of functionalized 1,6-enynes. The reaction leads to carbo- and heterocyclic amino derivatives in good to excellent yields. The cyclizations were conducted in the presence of PPh(3)AuCl/AgSbF(6) catalyst in THF or dioxane at room temperature. The use of allyloxycarbonyl carbamate has allowed the formation of free amino derivatives via sequential Au- and Pd-catalyzed reactions.
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