Synthesis of the Antimalarial Drug FR900098 Utilizing the Nitroso-Ene Reaction
Organic Letters2007Vol. 9(21), pp. 4379–4382
Citations Over TimeTop 24% of 2007 papers
Andrey A. Fokin, A. G. Yurchenko, V. N. Rodionov, Pavel A. Gunchenko, R. I. Yurchenko, Armin Reichenberg, Jochen Wiesner, Martin Hintz, Hassan Jomaa, Peter R. Schreiner
Abstract
The antimalarial drug FR900098 was prepared from diethyl allylphosphonate involving the nitroso-ene reaction with nitrosocarbonyl methane as the key step followed by hydrogenation and dealkylation. The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further.
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