Synthesis of the C1−C52 Fragment of Amphidinol 3, Featuring a β-Alkoxy Alkyllithium Addition Reaction
Organic Letters2007Vol. 9(23), pp. 4757–4760
Citations Over TimeTop 11% of 2007 papers
Abstract
An advanced intermediate for the synthesis of amphidinol 3 has been prepared. A cross-metathesis reaction was used to couple the C1-C12 and C13-C26 segments. An unusual beta-alkoxy alkyllithium reagent was generated from this segment and added to a Weinreb amide to assemble the C1-C52 section of amphidinol 3. These compounds represent some of the most advanced intermediates reported to date for the synthesis of amphidinol 3.
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