A Tandem Cross-Coupling/SNAr Approach to Functionalized Carbazoles
Organic Letters2007Vol. 9(23), pp. 4893–4896
Citations Over TimeTop 10% of 2007 papers
Abstract
A novel route to functionalized carbazoles utilizing a tandem Suzuki cross-coupling/SNAr protocol is described. This process was found to be compatible with a variety of electron-withdrawing groups including aldehydes, esters, and sulfones. Using this method, a concise total synthesis (four steps, 50% overall yield) of the carbazole alkaloid glycosinine was achieved.
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