Elaboration of 2-(Trifluoromethyl)indoles via a Cascade Coupling/Condensation/Deacylation Process
Organic Letters2008Vol. 10(4), pp. 625–628
Citations Over TimeTop 1% of 2008 papers
Abstract
CuI/l-proline-catalyzed coupling of 2-halotrifluoroacetanilides with beta-keto esters in anhydrous DMSO under the action of Cs2CO3 at 40-80 degrees C produces polysubstituted 2-(trifluoromethyl)indoles in good to excellent yields. This reaction is suggested to occur via a novel coupling/condensation/deacylation mechanism, and many functional groups are tolerated under these conditions.
Related Papers
- → Elaborating on Elaboration: The Distinction between Relational and Item- Specific Elaboration(1991)108 cited
- The Effects of Verbal Elaboration and Visual Elaboration on Student Learning(1997)
- On the Elaborate Way of Cifu(2002)
- → The Effect of Elaboration on Memory: Self-Generated Elaboration vs Experimenter-Provided Elaboration(2021)
- → EFFECT OF WITHIN-ITEM SOCIAL ELABORATION ON INCIDENTAL MEMORY(2021)