High-Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor
Organic Letters2008Vol. 10(8), pp. 1589–1592
Citations Over TimeTop 10% of 2008 papers
Csaba Csajági, Bernadett Borcsek, Krisztián Niesz, Ildikó Kovács, Zsolt Székelyhidi, Z. Bajkó, László Ürge, Ferenç Darvas
Abstract
Halogenated aryl carboxylic acids were efficiently converted to the corresponding dicarboxylic acid monoamides by a one-step Pd-catalyzed aminocarbonylation in a micro/meso fluidic continuous flow reactor (X-Cube) operated at high pressure and high temperature with CO gas introduction. Reaction parameters (solvent, base, catalyst, pressure, temperature) were rapidly optimized in the reactions, which required less than 2 min. The method gave improved results over comparable batch techniques and is also suited to automated parallel syntheses of compound libraries.
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