Ruthenium-Catalyzed One-Pot Carbenoid N−H Insertion Reactions and Diastereoselective Synthesis of Prolines
Organic Letters2008Vol. 10(8), pp. 1529–1532
Citations Over TimeTop 10% of 2008 papers
Abstract
Aryl- and aliphatic-substituted 3-hydroxyprolines and various other amino esters are conveniently prepared by [RuCl2(p-cymene)]2-catalyzed one-pot intramolecular and intermolecular carbenoid N-H insertion reactions, respectively, and the prolines are formed with high diastereoselectivities. The catalytic reactions are tolerant toward air/moisture, and the product yields are insensitive to the organic solvents used.
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