Gold-Catalyzed Double Migration-Benzannulation Cascade toward Naphthalenes
Organic Letters2008Vol. 10(7), pp. 1465–1468
Citations Over TimeTop 10% of 2008 papers
Abstract
A novel gold(I)-catalyzed cycloisomerization of propargylic esters leading to unsymmetrically substituted naphthalenes has been developed. This cascade reaction involves an unprecedented tandem sequence of 1,3- and 1,2-migration of two different migrating groups. It is believed that this transformation likely proceeds via the formation of 1,3-diene intermediate or its precursor, which upon cyclization and aromatization steps transforms into the naphthalene core.
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