Intramolecular Azide−Alkyne Cycloaddition for the Fast Assembly of Structurally Diverse, Tricyclic 1,2,3-Triazoles
Organic Letters2008Vol. 10(8), pp. 1617–1619
Citations Over TimeTop 14% of 2008 papers
Ana I. Oliva, Ute Christmann, D. Font, Félix Cuevas, Pablo Ballester, Helmut Buschmann, Antoni Torrens, Susana Yenes, Miquel À. Pericàs
Abstract
The synthesis of novel tricyclic 1,2,3-triazoles starting from cyclic epoxides via the sequential azidolysis, propargylation and 1,3-dipolar cycloaddition is described. Derivatization by N-arylation reaction and the synthesis of enantiomerically pure compounds is also reported. Some of these compounds exhibit significant affinity for the sigma-1 receptor.
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