Synthesis of Maremycins A and D1 via Cycloaddition of a Nitrone with (E)-3-Ethylidene-1-methylindolin-2-one
Organic Letters2008Vol. 10(10), pp. 2043–2046
Citations Over TimeTop 10% of 2008 papers
Abstract
A concise synthesis of maremycins A and D1 has been accomplished via cycloaddition of a chiral cyclic nitrone with ( E)-3-ethylidene-1-methylindolin-2-one as a key step. This synthesis clarifies the stereochemistry of the maremycins and is suitable for large-scale synthesis for biological screening.
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