Ainsliadimer A, A New Sesquiterpene Lactone Dimer with an Unusual Carbon Skeleton from Ainsliaea macrocephala
Organic Letters2008Vol. 10(12), pp. 2397–2400
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Zhi‐Jun Wu, Xi‐Ke Xu, Yun‐Heng Shen, Juan Su, Jun‐Mian Tian, Shuang Liang, Hui‐Liang Li, Rui‐Hui Liu, Weidong Zhang
Abstract
A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.
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