A Direct Stereoselective Approach totrans-2,3-Disubstituted Piperidines: Application in the Synthesis of 2-Epi-CP-99,994 and (+)-Epilupinine
Organic Letters2008Vol. 10(12), pp. 2473–2476
Citations Over TimeTop 10% of 2008 papers
Abstract
A simple synthesis of enantiomerically pure piperidine esters is described, offering a straightforward access to the trans-2,3-disubstituted piperidine skeleton which is present in a broad range of biologically active compounds.
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