Ruthenium-SYNPHOS-Catalyzed Asymmetric Hydrogenations: an Entry to Highly Stereoselective Synthesis of the C15−C30 Subunit of Dolabelide A
Organic Letters2008Vol. 10(17), pp. 3911–3914
Citations Over TimeTop 13% of 2008 papers
Abstract
An efficient construction of the C15-C30 segment of the cytotoxic macrolide dolabelide A is described. The synthesis relies on ruthenium-SYNPHOS-mediated asymmetric hydrogenation reactions of beta-keto esters to generate the C19, C21, and C27 hydroxyl-bearing stereocenters with very high levels of enantio- and diastereoselectivity.
Related Papers
- → Ligand control of metal oxidation states. Synthesis, characterization and cyclic voltammetric studies of a group of ruthenium phenolates(1996)18 cited
- THE FEATURES OF PROTEIN BINDING BY RUTHENIUM COMPLEXES: DOCKING, FORCE FIELD AND QM/MM STUDIES(2013)
- → ChemInform Abstract: Synthesis, Reactivities, and Structural Studies on High‐Valent Ruthenium Oxo Complexes. Ruthenium(IV), Ruthenium(V), and Ruthenium(VI) Oxo Complexes of Tertiary Amine Ligands.(1987)
- → Well-Defined Surface-Bonded Ruthenium Complexes with Molecular Nitrogen(1998)
- → ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ(2024)