Catalytic Asymmetric Conjugate Addition of Grignard Reagents to α,β-Unsaturated Sulfones
Organic Letters2008Vol. 10(19), pp. 4219–4222
Citations Over TimeTop 10% of 2008 papers
Abstract
A highly efficient method is reported for the asymmetric conjugate addition of Grignard reagents to alpha,beta-unsaturated 2-pyridylsulfones. Using a Cu/TolBinap complex, excellent enantioselectivities and high yields are obtained for a wide variety of aliphatic substrates.
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