Total Synthesis of (−)-Histrionicotoxin 285A and (−)-Perhydrohistrionicotoxin
Organic Letters2008Vol. 10(19), pp. 4227–4229
Citations Over TimeTop 12% of 2008 papers
Abstract
Starting from commercially available ( S)-glycidol, and via a common intermediate, the total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin has been achieved. Key to this synthesis was the efficient construction of a six-membered, chiral, cyclic nitrone.
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