Asymmetric, Organocatalytic, Three-Step Synthesis of γ-Hydroxy-(E)-α,β-Unsaturated Sulfones and Esters
Organic Letters2008Vol. 10(20), pp. 4685–4687
Citations Over TimeTop 13% of 2008 papers
Abstract
Efficient and enantiocontrolled synthesis of gamma-hydroxy-alpha,beta-unsaturated sulfones and esters are reported through the reaction of enantioenriched alpha-selenyl aldehydes with EWG-stabilized carbanions and then a one-pot selenide oxidation, in situ epoxide formation, and final in situ epoxide opening.
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