Synthesis and Antifungal Activity of (−)-(Z)-Dysidazirine
Organic Letters2008Vol. 10(22), pp. 5269–5271
Citations Over TimeTop 21% of 2008 papers
Abstract
A short, flexible synthesis of the marine natural product (2 R)-(Z)-dysidazirine (-)-1 has been completed. (-)-1 shows significant antifungal activity across a panel of seven human pathogens, whereas the structural analogue (-)-2, featuring a terminal tert-butyl group, is essentially inactive.
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