Palladium-Catalyzed Benzylic Arylation of N-Benzylxanthone Imine
Organic Letters2008Vol. 10(20), pp. 4689–4691
Citations Over TimeTop 15% of 2008 papers
Abstract
The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation represents a formal cross-coupling reaction of aryl halide with alpha-aminobenzyl metal.
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