Synthesis of a New Water-Soluble Oligo(phenylenevinylene) Containing a Tyrosine Moiety for Tyrosinase Activity Detection
Organic Letters2008Vol. 10(23), pp. 5369–5372
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Xuli Feng, Fude Feng, Minghui Yu, Fang He, Qingling Xu, Hongwei Tang, Shu Wang, Yuliang Li, Daoben Zhu
Abstract
A new water-soluble oligo(phenylenevinylene) containing a tyrosine unit (OPV-Tyr) was synthesized as a fluorescent probe to optically detect tyrosinase activity. Upon the addition of tyrosinase, the tyrosine moiety was oxidized to quinone, which quenched the fluorescence of OPV-Tyr via intramolecular electron transfer from the phenylenevinylene unit to the quinone site. OPV-Tyr was elaborated to detect tyrosinase activity both in aqueous buffer solution and in agarose gel.
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