Enantioselective Total Synthesis of (+)-Cassiol
Organic Letters2008Vol. 11(2), pp. 293–295
Citations Over TimeTop 10% of 2008 papers
Abstract
An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd(2)(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps.
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